IRAP II™ System

Defects in articular cartilage can induce osteoarthritis by causing molecular changes in the synovial fluid. Research in molecular biology discovered the major inducer of osteoarthritis was the general inflammatory cytokine interleukin-1 (IL-1) which plays a key role in accelerating tissue destruction and the repair mechanisms.

In a healthy joint, IL-1 and interleukin-1 receptor antagonist (IL-1Ra) are in balanced concentrations. In cases of osteoarthritis, there is not sufficient IL-1Ra produced to block the destructive effects of the increased IL-1. The result is inflammation, joint pain, and eventually cartilage destruction. In the IRAP II system, monocytes (a type of white blood cell) bind to the glass beads. The cells are then stimulated to produce regenerative and anti-inflammatory proteins without the addition of drugs. This process takes place over an incubation period of 24 hours.

IRAP II is used to treat mild to moderate osteoarthritis in animals.

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Defects in articular cartilage can induce osteoarthritis by causing molecular changes in the synovial fluid. Research in molecular biology discovered the major inducer of osteoarthritis was the general inflammatory cytokine interleukin-1 (IL-1) which plays a key role in accelerating tissue destruction and the repair mechanisms.

In a healthy joint, IL-1 and interleukin-1 receptor antagonist (IL-1Ra) are in balanced concentrations. In cases of osteoarthritis, there is not sufficient IL-1Ra produced to block the destructive effects of the increased IL-1. The result is inflammation, joint pain, and eventually cartilage destruction. In the IRAP II system, monocytes (a type of white blood cell) bind to the glass beads. The cells are then stimulated to produce regenerative and anti-inflammatory proteins without the addition of drugs. This process takes place over an incubation period of 24 hours.

IRAP II is used to treat mild to moderate osteoarthritis in animals.

View More

Educational Resources and Products

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Surgical Technique Videos (1)

ARTHREX VET SYSTEMS IRAP II
Arthrex Vet Systems IRAP II
Hank Gendron, DVM
03:57 | English | 07/25/2017 | VVID1-01134-EN A

Surgical Technique Animations (1)

IRAP II™ Autologous Blood Processing System
IRAP II™ Autologous Blood Processing System
01:39 | English | 07/03/2017 | AN1-00240-EN A

Brochures (2)

Arthrex IRAP™  ProEAS™  System Surgical Technique
Arthrex IRAP™ ProEAS™ System Surgical Technique
English | 07/26/2021 | vLB1-000002-en-US C
The IRAP II System - Autologous Blood Processing System
The IRAP II System - Autologous Blood Processing System
English | 10/21/2019 | VLB1-0010-EN E

Catalogs (1)

Vet Systems Product Catalog
Vet Systems Product Catalog
English | 04/21/2023 | VLB1-0001-EN H

Presentation Videos (1)

Use of Biologics in Small Animal Orthopaedics
Use of Biologics in Small Animal Orthopaedics
James L. Cook, DVM, PhD
23:08 | English | 07/26/2017 | VVPT1-00921-EN A

Scientific Updates (1)

IRAP for Veterinary Applications Scientific Update
IRAP for Veterinary Applications Scientific Update
English | 07/13/2023 | vDOC1-001110-en-US A

WebInHours (1)

Biologics Play a Role in Intraoperative and Postoperative Management in Tendon Injury
Biologics Play a Role in Intraoperative and Postoperative Management in Tendon Injury
Samuel P. Franklin, DVM | Lauren Schnabel, DVM, DACVS | John Peroni, DVM, DACVS
01:00:44 | English | 08/12/2020 | vVID1-001432-en-US A

White Papers (4)